Exam 1 Research Paper Example | Topics and Well Written Essays - 2000 words

Exam 1 - Research Paper Example This event requires adequate replacement mechanisms for the economic continuity of the nation. Chronological trends indicate that replacement of the retired workforce has been a challenge to the regime. The low application turnout towards governmental vacancies has been attributable to the negative perspective from college graduates. The graduated professionals from colleges have a very low opinion towards serving the regime. Most of these seniors from college do not have a vivid understanding of government jobs. Additionally, the government takes an extremely lengthy duration to recruit a single employee. In this case, the government ought to implement strategies to attract college graduates and professionals towards the available posts in agencies. The government should shorten the recruitment span. This would entail superficial recruitment of workers without investigating the individual in great depths. A span of probation would determine whether the individual deserves the post. Additionally, the government should also educate the college graduates about serving in diverse posts. This would inculcate a new perspective of serving the government into the college graduates. Pay banding The General schedule has dictated on the compensation channels to the employees serving in the regime. Under the schedule, the level step of an employee determines the payment. The time of experience within the post determines the step of the employee. For instance, a one year old employee in service might belong to step one. This philosophy surfaced much focus on time spent in service, rather than an individual’s performance. Managers have minimal discretion, while technicians express immense authority within the urgency. The technicians decided the grade of equipment to a department in the agency. Pay band strategies performed a replacement of the General Schedule. These strategies oversaw the delegation of much authority and support to the managers. The strategies also focused on performance of an employee to determine payment. Pay banding initiated immense advantage even to the recruitment process. This system required new recruits to receive their pay according to their range within the agency. Consequently, it would appeal for more attention and attraction from the college graduates and talents. Evidently, this was a remedy to the concept of the General schedule. Category rating In this system, line managers have utmost authority towards the recruitment procedure. This system was a remedy to traditional methodologies of recruitment within agencies. The traditional methodologies used the philosophy of â€Å"rule of three.† According to this principle, the recruitment process involved picking three best candidates. This was regardless of the close performers of the top applicants. Category rating implemented a new strategy of grouping the applicants according to their performance. For instance, there would be clusters of â€Å"highly qua lified,† â€Å"qualified,† and â€Å"not qualified.† This would give the appointing manager a platform to choose an individual from the top category. Upon exhausting the first list, the manager has an alternative to choose from the subsequent category. This was an outstanding recommendation for the governmental agencies. The selection procedure is more accurate and fair. Question 2 Government agencies have the capacity of maintaining well-adjusted and trained workforce. The government

Pharmacological Profiles of Several Common Drugs

Pharmacological Profiles of Several Common Drugs 2.3 Profile of Pheniramine Maleate (31) Chemical name: (3RS)-N,N-Dimethyl-3-phenyl-3-(pyridine-2-yl)propan-1-amine(Z)-butenedioate Empirical formula: C20H24N2O4 Chemical structure: Figure 2.3:Structure of Pheniramine Maleate 2.3.1 Physical properties Molecular weight: 356.4 Appearance and colour: White or almost white crystalline powder. Solubility: Very soluble in water, freely soluble in ethanol (96 %)in methanol and in methylene chloride. Therapeutic category:Pheniramine maleate belongs to H1-antagonist pharmacological group on the basis of mechanism of action and also classified in Antihistamine, Decongestant. Dosage: Tablet , Powder, Solution 2.3.2 Pharmacology Pheniramine maleate is an antihistamine used for alleviation of allergy symptoms. Manufacturers frequently list the over-the-counter medication as pheniramine maleate or a derivative. Drug industries also often combine the formulation with other medications for relief of other symptoms. Consumers can generally find the ingredient in an oral solution or tablet form. Certain ophthalmic solutions also contain pheniramine maleate, which provides relief from allergy symptoms associated with the eyes. Allergic reactions are autoimmune responses to certain antigens. When allergens enter the bloodstream, the body releases histamine, which binds with and activates receptor sites, located throughout the body, producing physical symptoms. The pharmacological action of pheniramine maleate involves blocking the receptor sites for the histamine H1, found in the heart, central nervous system, smooth muscle, and vascular endothelium cells. Blocking the receptor sites reduces or inhibits the symptoms. The antihistamine is frequently used for seasonal allergies, such as hay fever, or environmental allergies, such as animal dander. By blocking histamine receptor sites, pheniramine maleate can reduce or eliminate itching, watery eyes, runny noses, and skin irritations. Allergy related skin irritations might include the itching, redness, and swelling associated with eczema or uticaria, commonly referred to as hives (40). The medication may produce a sedative effect when binding to sites in the central nervous system. It also may produce an anticholinergic effect by dilating or relaxing smooth muscle. These side effects sometimes allow pheniramine maleate to be used as treatment for motion sickness or the inner ear condition known as Meniere’s disease. 2.4 Profile of Phenylephrine Hydrochloride (78) Chemical name:(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride Empirical formula:C9H13NO2HCL Chemical structure: Figure 2.4 : Structure of Phenylephrine Hydrochloride 2.4.1 Physical properties Molecular weight:203.67 Appearance and colour: White or practically white odourless crystals Solubility: Freely soluble in water and alcohol Therapeutic category: Phenylephrine is a sympathomimetic amine that acts predominantly on ÃŽ ±-adrenergic receptors. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs. Dosage: Cream, Solution, Ointment, Injection, Liquid, Tablet, Suppository 2.4.2 Pharmacology In general, ÃŽ ±1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. ÃŽ ±1-receptors are 7-transmembrane domain receptors coupled to G proteins, Gq/11. Three ÃŽ ±1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: ÃŽ ±1A (chromosome 8), ÃŽ ±1B (chromosome 5), and ÃŽ ±1D (chromosome 20). Phenylephrine appears to act similarly on all three receptor subtypes. All three receptor subtypes appear to be involved in maintaining vascular tone. The ÃŽ ±1A-receptor maintains basal vascular tone while the ÃŽ ±1B-receptor mediates the vasocontrictory effects of exogenous ÃŽ ±1-agonists. Activation of the ÃŽ ±1-receptor activates Gq-proteins, which results in intracellular stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2+ from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and subsequent vasoconstriction. Phenylephrine produces its local and systemic actions by acting on ÃŽ ±1-adrenergic receptors peripheral vascular smooth muscle. Stimulation of the ÃŽ ±1-adrenergic receptors results in contraction arteriolar smooth muscle in the periphery. Phenylephrine decreases nasal congestion by acting on ÃŽ ±1-adrenergic receptors in the arterioles of the nasal mucosa to produce constriction; this leads to decreased edema and increased drainage of the sinus cavities. 2.5 Profile of Dextromethorphan (79) Chemical name:(1R,9R,10R) 4 methoxy 17 methyl – 17 azatetracyclo[7.5.3.0{1,10}.0{2,7}]heptadeca-2,4,6-triene Empirical formula:C18H25NO Chemical structure: Figure 2.5 : Structure of Dextromethorphan 2.5.1 Physical properties Molecular weight:271.39 Appearance and colour: It is a White crystalline powder Solubility: 1-5 g/100 mL at 21 Â ºC Therapeutic category: Dextromethorphan usually used in the treatment of respiratory infections and allergic conditions Dosage: Tablet , Syrup, Capsule, Suspension 2.5.2 Pharmacology Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan. 2.6 Profile of Diphenhydramine (80) Chemical name: 2-(diphenylmethoxy)-N,N-dimethylethanamine Empirical formula:C17H21NO HCL Chemical structure: Figure 2.6 : Structure of Diphenhydramine 2.6.1 Physical properties Molecular weight:291.82 Appearance and colour: It is a White crystalline powder Solubility: Soluble in DMSO, acetone, water Therapeutic category: Diphenhydramineis a first-generationantihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties that is mainly used to treat allergies. It is also used in the management of drug-induced parkinsonism and other extrapyramidal symptoms. The drug has a strong hypnotic effect and is FDA-approved as a non-prescription sleep aid, especially in the form of diphenhydramine citrate Dosage: Capsule 2.6.2 Pharmacology Diphenhydramine is an inverse agonist of the histamineH1receptor. It is a member of the ethanolamine class of antihistaminergic agents. By blocking the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. Diphenhydramine also crosses the blood–brain barrier (BBB) and antagonizes the H1 receptors centrally. Its effects on central H1 receptors cause drowsiness. Like many other first-generation antihistamines, diphenhydramine is also a potent antimuscarinic (a competitive antagonist of muscarinic acetylcholine receptors), and, as such, at high doses can cause anticholinergic syndrome. The utility of diphenhydramine as

The Transcontinental Railroad Essay -- Transportation, Railroad Compa

The Transcontinental railroad could be defined as the most monumental change in America in the 19th century. The railroad played a significant role in westward expansion and on the growth and development of the American economy (Gillon p.653). However, the construction of the transcontinental railroad may not have occurred if not for the generous support of the federal government. The federal government provided land grants and financial subsidies to railroad companies to ensure the construction. The transcontinental railroad contributed to the formation of industry and the market economy in America and forever altered the American lifestyle. The Pacific Railroad bill of 1862 launched the transcontinental railroad construction project. The Pacific Railroad bill granted 6,400 acres of public lands and government loans ranging from $16,000 to $48,000 per mile of track completed to the Union Pacific Railroad and Central Pacific Railroad companies. (Pacific Railroad Bill) Following the Pacific Railroad bill a series of federal and state acts between 1862 and 1871 granted more than 130 million acres of public land and supplied additional monetary loans of approximately $150 million dollars to the expansion of the railroads. (Gillon p.652) There is no refuting that the railroad companies transformed business operations and encouraged industrial expansion. The raw materials required for construction of the transcontinental railroad directly resulted in the expansion of the steel, lumber and stone industries. (Gillon p.652) The railroad stimulated growth in manufacturing and agriculture providing an efficient manner to ship raw materials and products throughout the country. Which in turn, increased consumerism and introduced t... ...ich developed new corporations. (Gillon p.652) Many in the railroad industry and these newly developed corporations were accused of price fixing, providing illegal kick- backs and challenging government regulations. (Gillon p.652-657) Thus, one could argue that the railroad industry and the titans it produced had a monopolistic approach to business that actually challenged the free market system. In the end, the transcontinental railroad changed the American landscape both physically and culturally. It formed the foundation for the industrial economy, it produced new business practices and management style of large workforces. It helped established government regulations, taxation and support of public transportation. Above all it drastically changed the American lifestyle, changed where people lived, how they shopped, how they ate, and how they worked.

Marriage in Jane Austen’s Pride and Prejudice Essay

The intricate nexus of marriage, money and love in Jane Austen’s society is unfolded through the development of plots and characters of her novel Pride and Prejudice. In the nineteenth century’s rural England, marriage was a woman’s chief aim, both financially and socially. Financially because of women’s dependent position marriage was the â€Å"only honourable position†, infinitely preferable to the dependence of precarious shabby-genteel spinsterhood. Money was, therefore, a very significant aspect of Austen’s society, especially when marriage was concerned. â€Å"A single man of large fortune† was naturally considered as â€Å"a nice thing† for the unmarried girls. Partners were chosen for what might now seem unemotional reasons: fortune and connections, similar to, but preferably better than one’s own. By representing a series of marriages, Austen in this novel unearths and elucidates different aspects of the role of marriage, money and love in her society. Austen was a realist and painted her time as they were. In this novel, love and money-based Darcy-Elizabeth marriage is the most successful one whereas the marriage of Elizabeth’s parents, Mr. and Mrs. Bennet, is one of the faulty ones. Mr. Bennet married his wife being â€Å"captivated† and tempted by her â€Å"youth, beauty† and physical appearance. He forgot that the first appeal of a pretty face does not last long unless serenity of mind and sweetness of temper provide more enduring powers of attraction. Moreover, Mrs. Bennet inherited no property. So, form every point of view, this marriage is a failure. Mr. Bennet, therefore, always has to endure her â€Å"weak understanding†, vulgarity to such and extreme degree that he has nothing to revel in except confining himself to his library all the day, and thus eluding the necessary rituals of family and society. Charlotte’s loveless matrimony for financial security with the pompous Collins is another interesting marriage. Being twenty-seven and plain looking and realizing that it is her last chance, she accepts the grotesque Mr. Collins, to whom the role of romance and love in life is beyond the reach. He only wants a wife, because in the eyes of the society it is time for him to settle and be married. Charlotte knows that apart from some kind of security and happiness, marriage gives a woman a position. She has few hopes of happiness in marriage beyond the material comfort it can give and so she marries Collins who is inferior in intelligence, only for the ‘home and position’ he offers, as she believes â€Å"Happiness in marriage is entirely a matter of chance†. The marriage and money theme operates in a baffling way when Elizabeth herself comes to marry. When she sees Pemberly, her ‘prejudice’ against Darcy begins to be ‘subdued’ and later by accepting him she makes the most glorious match of and of Austen’s heroines. The fact that Darcy has then thousand pounds a year is not to be ignored; it emphasizes the perfect adjustment between personal and social ambition achieved by Elizabeth. [Actually Jane Austen understood better than any other of her contemporary English novelists the degree to which social and personal behaviors and even emotion depend on the economic framework of the society.] Moreover, in her marriage with Darcy, affection and understanding, financial security and social engagement are juxtaposed. But to achieve all these material things she has never turned herself into a â€Å"husband-hunting butterfly† despite her mother’s inducement. Although she is aware of the fact that in her society a senile spinster, without any fortune, is faced with the prospect of a bleak future full of deprivation and humiliation, still she is the bold heroine who at first showed courage to refuse two marriage proposals. To Austen, sexuality was far less vital to relationships than its counterpart, affection. Therefore, Lydia’s ex-based marriage with the seductive but penniless Wickham later turns out to be an unsuccessful ones. Wickham’s plausible appearance even overwhelmed Elizabeth once. His former interest in Miss King and her â‚ ¤ 10,000 dowry alludes to the role of money in marriage. He only takes Lydia to London only for physical enjoyment. As a consequence, their marriage ends in his going â€Å"to enjoy himself in London† and Lydia’s patent failure in managing her household financially despite Darcy and Elizabeth’s continuous help. The Bingley-Jane marriage is another example of good marriage, like the Darcy- Elizabeth marriage, where mutual understanding, romance and financial  stability are combined. Their affection-based marriage works as both are perfectly amiable, modest and gentle. The established marriage of the Gardiners is too shadowy to have a dramatic role. We are only dimly aware of it as a satisfactory relationship between two apparently similar type of persons. In â€Å"Pride and Prejudice† we experience different marriages in the light of one another. Austen presents all the material for an al-round understanding and view: Jane and Elizabeth, combing love and marriage, Charlotte marries for safety, Lydia repenting at leisure. The married couples are equally varied, from well-matched like the Gardiners to ill-suited like the Bennets. The novel says in effect that the real object of love and marriage is not only financial security or physical passion or romance, but also the self-development that true relationships bring about. A marriage can only become an institution when it provides for the fulfillment of both men and women’s aspirations, sanctified by love and validated by prudence that both Elizabeth Bennet and Mr. Collins can live on, the former drinking deep draughts of life’s fullness, the later continuing to sip its littleness. The richness of Pride and Prejudice lies in that exploration of life and marriage by Jane Austen.

An Abuse of Power Essay

Abigail is the most prominent example of power and manipulation, with far worse repercussions, fooling the court and pretending to be God’s voice to get what she wants. Hale declares before the court that â€Å"private vengeance is working through this testimony,† (105) when Proctor attempts to show the court Abigail’s machinations. She recognizes the Puritan’s fear of God, and their fear of witches, to manipulate those in power, gaining her own strength in the court and causing mass hysteria to turn in her favor. Her rise to power begins even before the hysteria, starting with the group of girls from the forest, but her tactics are no different: manipulate others to save herself. They fear being caught, and she plays to their terror, telling them if they â€Å"breathe a word, or the edge of a word, about the other things, [then she] will come to [them] in the black of some terrible night and [she] will bring a pointy reckoning that will shudder [them]† (19). This threat crafts her iron grip on the girls, allowing her to lead them against the town, lying and condemning folk to save themselves from strife over their actions. Abigail’s hold remains on the girls all through the play, forcing even the most honest to turn from truth and continue their lies â€Å"when people accused of witchery confronted [them] in court, [they] would faint, saying their spirits came out of their bodies and choked [them]† (98). This is evident in the scene where Mary confesses their lies, admitting they â€Å"never saw no spirits† and â€Å"were never threatened or afflicted by any manifest of the Devil or the Devil’s agents† (98). Abigail manipulates the court, using the power she’s gained to say she does God’s work, and Mary falls back to her, carrying out Abigail’s wishes by condemning John Proctor. This is similar to how Abigail got rid of Elizabeth by accusing her in her newfound place of power, so she could be with John, a fact that he addresses, refusing to â€Å"give [his] wife to vengeance† (73) when they come to arrest her. Abigail’s attitude of controlling the girls by vicious fear of witchery is easily comparable to that of the boy Jack in Golding’s Lord of the Flies. Jack recognizes the weakness in the group of boys, using their gnawing fear of â€Å"the beast† to turn them to his side, against Ralph. Though much more direct, Jack uses his power to threaten the boys on Ralph’s side, such as Samneric, to hail to savagery and chaos, much like Abigail did to Mary. He dominates the island, getting what he wants, and eliminating those such as Piggy and Ralph, who stand in his way. Abigail’s tactic of lying, manipulating fear and abusing her power in court grants her the same reward of getting her way, and pushing aside enemies like Elisabeth. The only difference is that Abigail’s actions come with far bigger consequences, more than Parris, Putnam or Danforth, fleshed out on a larger scale of victims who fell in the face of her machinations. In the end, Arthur Miller’s Crucible is a fine study of manipulation and abuse of power, shown in various forms, through vicious antagonists, always exploiting Salem’s fear to achieve their own selfish goals and further themselves on the social food chain. What Miller is perhaps attempting to demonstrate through this play is that those in positions of power will always abuse it, especially when faith is involved, because of the â€Å"manipulation of that faith to create fear and control† (Bardem), as have done Danforth, Parris, Putnam and Abigail.